This report puts forward recommendations for how the US government can better address climate change through its policies on global agricultural development. It argues for the United States to rally international resources and deploy its agricultural research enterprise—its universities, research institutes, and agrifood businesses—to gather more information about how climate change will affect the global food system and develop the innovations to manage its impacts. It presents evidence that by enhancing the public sector’s partnerships with businesses and civil society, solutions that benefit populations around the world, from farmers in Africa to those in the United States, can be found.