This paper reports on a study that examined teachers’ concerns and attitude toward inclusive education of students with disabilities in Ghana. A 20 item Attitudes Toward Inclusion in Africa Scale (ATIAS) was completed by 100 teachers from five ‘Inclusive Project’ schools and five Non-Project coeducational basic schools in three different localities; central business, coastal and suburban areas within the Greater Accra metropolis. Analysis of the responses indicated four factors: Behavioural Issues, Student Needs, Resource Issues and Professional Competency. Interviews were also conducted with a small sample of the teachers in order to extend the understanding of their attitude and concerns. The study showed that attitudes and concerns of teachers affect their acceptance and commitment to implementing inclusion. The paper draws on the findings to provide recommendations for improving practice in inclusive based classrooms.